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Applicability of first-trimester combined screening for fetal trisomy 21 in a resource-limited setting in mainland China. Li B, Sahota DS, Lao TT, Xu J, Hu SQ, Zhang L, et al. Integration of suboptimal health status evaluation as a criterion for prediction of preeclampsia is strongly recommended for healthcare management in pregnancy: a prospective cohort study in a Ghanaian population. 2014 5(1):8.Īnto EO, Roberts P, Coall D, Turpin CA, Adua E, Wang Y, et al. Towards personal health care with model-guided medicine: long-term PPPM-related strategies and realisation opportunities within ‘Horizon 2020’. Predictive, preventive and personalized medicine as the hardcore of ‘Horizon 2020’: EPMA position paper. Golubnitschaja O, Kinkorova J, Costigliola V. Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction. Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa: a prospective cohort study. Nathan HL, Seed PT, Hezelgrave NL, De Greeff A, Lawley E, Conti-Ramsden F, et al. Contribution of hypertension to severe maternal morbidity. Hitti J, Sienas L, Walker S, Benedetti TJ, Easterling T. The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP. Tranquilli AL, Dekker G, Magee L, Roberts J, Sibai BM, Steyn W, et al. Angiogenic and antiangiogenic factors in preeclampsia. Helmo FR, Lopes A, Carneiro A, Campos CG, Silva PB, Dos RMM, et al.
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Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches. 2018 5(1):3.Īrmaly Z, Jadaon JE, Jabbour A, Abassi ZA.
#SCREEN MARKER TOOL ORS UPDATE#
Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal. Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance. Webster K, Fishburn S, Maresh M, Findlay SC, Chappell LC.
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#SCREEN MARKER TOOL ORS SERIES#
In our study, we found that the combination of a series of prenatal screening markers in early pregnancy is better than a single marker our data clearly demonstrate the diagnostic value of combining PAPP-A, free β-hCG, and NT for patients with SPE. The development of innovative screening strategies for gravidas and the targeted prevention of HDPs in high-risk gravidas are essential for perinatal care and early intervention, thus creating significant opportunities for predictive and preventive personalized medicine. The use of prenatal screening markers during early pregnancy can identify fetal aneuploidy and can also predict HDPs. The best risk calculation featured PAPP-A, free β-hCG, and NT this model exhibited the highest diagnostic value in the SPE group, followed by the GH group and then the PE group. When the cut-off values for PAPP-A and free β-hCG were 0.795 MoM and 1.185 MoM, the corresponding sensitivities and specificities were 0.514 and 0.635, and 0.734 and 0.450, respectively. Levels of PAPP-A and free β-hCG levels in the GH, PE, and SPE groups were significantly lower than those in the control group ( χ 2 = 7.522, P = 0.001 χ 2 = 17.775, P 0.05). A risk model was constructed and receiver operating characteristic curve (ROC) analysis was used to diagnose HDPs. We then compared the multiple of median (MoM) of PAPP-A, free β-hCG, and NT. We analyzed 902 women, classified into four groups: healthy gravidas ( n = 680, controls), gravidas with gestational hypertension ( n = 61 GH), gravidas with preeclampsia ( n = 90 PE), and gravidas with severe preeclampsia ( n = 71, SPE). We aimed to construct a risk model to assess the diagnostic value of predicting hypertensive disorders of pregnancy (HDPs) by screening a range of prenatal markers, including pregnancy-associated plasma protein A (PAPP-A), free beta-human chorionic gonadotropin (free β-hCG), and fetal nuchal translucency (NT).